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The IS6110_T real-time PCR assay provides increased specificity over previously published IS 6110 assays with a sensitivity of 66.7%.
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By undertaking comparative studies on HupBMtb and a derivative that lacks 119 amino acids located at the C-terminal end, we provide evidence to show that this C-terminal region (CTR) of HupBMtb is required for providing increased specificity of DNA binding and for specific recognition of altered nucleic acid structures under stringent (high salt) conditions.
The specific structural features of stem-loop (hairpin) DNA constructs provide increased specificity of target recognition.
Fundamental to increasing our understanding of the role of white matter microstructure in normal/abnormal function in the living human is the development of MR-based metrics that provide increased specificity to distinct attributes of the white matter (e.g., local fibre architecture, axon morphology, and myelin content).
IGRAs provide increased specificity over TST, because the antigens used in the test do not cross react with BCG or other NTM.
Although limited by small sample size, our data suggests that careful measurement of HER2 levels could provide increased specificity in selection of patients for trastuzumab therapy.
We aim to implement this facility in our automated FLIM multiwell-plate reader where it could provide increased specificity for screens and systems biology.
First, the transition to the 10th revision of the International Classification of Disease (ICD-10) may provide increased specificity due to the greater granularity of available codes.
The development of new biomarker strategies that improve the diagnosis of DILI by providing increased specificity and/or by identifying individual patients who are at risk for DILI is therefore crucial.
The development of FISH methods to measure telomere length successfully solved some of the drawbacks of the TRF method, providing increased sensitivity, specificity, and resolution [ 25] (Table 1).
More recently, nucleic acid amplification tests (NAATs) in vitro can provide increased sensitivity and specificity of detection (van der Vliet et al. 1993; Ieven and Goossens 1997).
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