These findings validate pathogenesis-based therapy that provides the deficient end product and prevents accumulation of toxic metabolites, an approach of potential utility for other syndromic lipid metabolic disorders.
Simulations showed that the simplest dryer design in which air enters the bale through one end, provides a deficient air distribution and inadequate drying, even when the bale is perfectly formed.
Although remaining to be investigated, the host adaptation process most likely provides OspC-deficient spirochetes with both time and environment that enable the upregulation of other Osps, such as VlsE and BBF01, to occur during the course of disappearance of unstable ospC copies.
Expression of Cc-phr2 provided photolyase deficient Escherichia coli cells with photoreactivating activity indicating that Cc-phr2 encodes an active photolyase.
I have gone into this one figure in some detail, not at all to criticise the authors for providing a deficient figure, but to illustrate the extent to which the data from which the model can be built is lacking, together with the semantics needed to put that data to good use.
We are grateful to Dr. B. De Strooper for providing MEFs deficient in PS1 and 2 expression and their corresponding controls, to Dr. C.A. Saura for helpful comments and for reagents and to Dr. M. Campillo for supervision with statistical analysis.
An external assessment found the quality of the health care services provided was deficient.
We really appreciate Dr. F. Mollinedo for providing Fas-deficient Jurkat cells and Dr. B. Seed for providing parental and RIP-deficient Jurkat cells.
We are grateful to D. Ron and H. Harding (Institute of Metabolic Science, Cambridge, UK) for the gift of GCN2-, PERK- and C/EBPβ-deficient MEFs and to N. Jones and W. Breitwieser (Paterson Institute for Cancer Research, Manchester, UK) for providing ATF2-deficient MEFs.
