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However, sequence variation at the dimer dimer interface has profound consequences for the ligand binding site and provides a structural rationalisation for the absence of thyroid hormone binding affinity in bacterial TLPs: the deep, negatively charged thyroxine-binding pocket that characterises vertebrate TTR contrasts with a shallow and elongated, positively charged cleft in S. dublin TLP.
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Our results are consistent with this prediction and provide a structural rationalisation: the unpaired region is required to engage the U U step on the rim.
The sites correlate with extensive electrophysiological data and provide a structural basis for understanding rectification.
Bone scaffolds provide a structural support for tissue development.
Such extensive transcriptions may provide a structural explanation for Hox clustering.
The models provide a structural framework for interpretation of the resulting functional analysis.
This may provide a structural basis for an active site.
Our data provide a structural rationale for these observations.
Furthermore, the structural resolution of Bacillus stearothermophilus MutY has provided a structural basis for these variants [Fromme et al., 2004].
Our future studies are directed towards a structural rationalisation of this result and testing the biological utility of these metal complexes.
Colonial possessions did not in themselves provide a structural impediment to European integration, quite the reverse.
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