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This alteration to a key point of interaction with the activators, as evident in the crystal structure, provides a structural rationale for the measured selectivity.
The high-resolution structure of Fsβ-glucanase provides a structural rationale for the different activities obtained from a series of mutant glucanases and a basis for the development of engineered enzymes with increased activity and structural stability.
The crystal structure of S. aureus DHDPS in the free and substrate bound forms provides a structural rationale for its catalytic mechanism.
This provides a structural rationale for the observed similarities in the kinetic parameters (k2,slow, k3, k1, and k 1) for each individual GES enzyme with these three carbapenems, as only the core of the antibiotics appears to interact with the enzymes.
Similar(55)
The lack of a methyl group in the core structure of imipenem may provide a structural rationale for the increase in turnover of this carbapenem by the GES β-lactamases.
These findings provide a structural rationale for the observed activity of synthetic peptides based on these NT regions.
We have also provided a structural rationale for why natural mutations of E5D and S3T can elicit a similar T cell response as the wild type QW9 does.
Our data provide a structural rationale for these observations.
This provided a structural rationale for the different Chi-recognition specificities of AddAB and RecBCD complexes and new insights into sequence-specific ssDNA protein interactions.
The crystal structure of a mutant form of rat PheH lacking the 24 C-terminal residues confirmed the presence of discrete regulatory and catalytic domains and provided a structural rationale for phenylalanine activation.
These bases lined the minor groove of the codon anticodon helix in such a way that the geometry of base pairs is sensed at the first two positions, but not at the wobble position, providing a structural rationale for the wobble hypothesis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com