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The crystal structure provides a structural explanation for the observed trans-complementation of MTases with different methylation defects.
The structure presented provides a structural explanation for all loss of activity mutations covered in the sequence, although this information was not used for model generation.
The recent described X-ray structure of Cerulean [22] now provides a structural explanation for the described change in the fluorescence decay compared to the CFP variant.
It also provides a structural explanation for having an invariant Gly in that position as no other residue can normally lie in that region of Ramachandran map.
The similar binding mode of AM1 to that of ABA thus provides a structural explanation for their shared biological activities in activating stress-response programs in plants.
This structural arrangement provides a structural explanation for how the CT domain promotes motors dimerization, reminiscent of the Kinesin-1-tail domain interaction (Kaan et al., 2011).
Similar(52)
Indeed, the character of the S4 subsite provides a structural explanation of the preference for large and hydrophobic residues and the intolerance for polar residues in the P4 position of TatA (Fig 2A).
Thus, our crystal structure may provide a structural explanation for how distinct mutant MTases defective in N7 or 2'-O methylation could trans-complement one another, resulting in double methylated 7meGpppA2'-O-me product [33].
To provide a structural explanation for enhanced binding for pSer670 and pSer676, we did structural modeling by replacing the aspartate sidechains with phosphoserine.
Therefore, our results provide a structural explanation for the highly labile feature of cADO di-iron center, which we proposed to be related to its low enzymatic activity.
The hydrophobic N-substituent of β-lactam inhibitors points into a cavity within the enzyme, providing a structural explanation for the specificity of β-lactams on rhomboid proteases.
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