Exact(2)
This finding underscores the essential significance of B-cell nucleic acid sensors in loss of tolerance and production of autoantibodies in lupus and provides a specific target for intervention.
The identification of the recurrent point mutation that causes FOP in all classically affected individuals (∼98% of all known cases of FOP) provides a specific target for drug development (Kaplan et al., 2007b).
Similar(58)
This motif should be useful in identifying additional helminth hemoglobinases and may provide a specific target for drug design efforts.
The insulin-induced new channels provide a specific target for rescuing cognition in health and disease.
This would not only confirm the diagnosis; it would also provide a specific target for therapy.
The investigators deduced that the tin present in TPT interacts with the N-terminal threonine of the proteasomal β5 subunit, possibly providing a specific target for organotins.
In addition, our study introduces the Bmi-1 expression as a strong and independent molecular marker of prognosis in pediatric brain tumors in addition to providing a specific target site for targeting therapy.
The prognosis of breast cancer patients is highly variable, 1 HER-2 was discovered as a prognostic factor, 3 which provided a specific target for an intervention (trastuzumab), which was then evaluated in trials which recruited women with HER-2 positive cancers (see fig 1).
The difference in the disordered region and indels between H. sapiens and nematodes provides a specific mechanism for targeting O01427/Q19126.
As such, not only can these numbers be used as a true/false function similar to the binary "1/0" combination, the choice of a different prime number for each element/target/method provides a specific representation of each of them.
The Bergerat fold in the ATP-binding domain of HKs is not present in the abundant Ser/Thr and Tyr kinases, providing a specific kinase target within a human host.
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Justyna Jupowicz-Kozak
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