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GFOGER hydrogels provided sustained in vivo release of encapsulated BMP-2, increased osteoprogenitor localization in the defect site, enhanced bone formation and induced defect bridging and mechanically robust healing at low BMP-2 doses which stimulated almost no bone regeneration when delivered from collagen sponges.
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This method provided sustained elevations in baseline CORT in both LD and MD males compared to V males, with higher CORT levels induced in MD males.
The procedures were performed without complications and provided sustained improvement in arterial oxygen saturation and exercise tolerance on follow-up examination in all patients.
The procedure was technically easy, had no complications, and provided sustained improvement in arterial saturation and exercise tolerance during follow-up.
CZP provided sustained improvements in clinical outcomes for almost 5 years.
Rosiglitazone provided sustained decreases in long-term A1C compared with both glyburide and metformin; however, during the 1st year after commencement of treatment, A1C reduction was greatest with glyburide and least with rosiglitazone.
Further, sequential EGFR/ErbB treatment provided sustained clinical benefit in some patients, suggesting a lack of cross-resistance.
Sequential EGFR/ErbB treatment with afatinib and cetuximab provided sustained clinical benefit in patients after crossover, suggesting a lack of cross-resistance.
The absolute amount (Fig. 3) and cumulative release (Additional file 1: Figure S3) profile of rhBMP-2 (as measured by radioactive 125I-labeled rhBMP-2) over 23 days of either the PlnD1-conjugated PCL constructs or unmodified PCL scaffolds shown that PlnD1-conjugated PCL constructs provided sustained release of rhBMP-2 in PBS.
Both nanoparticles were around 150 nm in diameter and provided sustained Gemcitabine release for at least a week.
Browder et al. showed that cyclophosphamide-based MC provided sustained apoptosis of endothelial cells, resulting in eradication of Lewis lung carcinoma and L1210 leukemia [ 6].
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