NRs are highly druggable targets of synthetic and natural ligands, and accumulating insights on NR structures and functions and advances in medicinal chemistry have provided receptor-selective, full, partial and inverse agonists and antagonists, as well as compounds that activate only a subset of the NR functions or in a tissue-specific manner.
Let us imagine the existence of what we might name "timer units" (receptor subunits, proteins, channels…) that would provide receptors (or molecular structures that are activated by them) with distinct temporal activation profiles.
In systems lacking the adaptive arm of immunity, the pattern recognition concept serves well to explain the general triggering of the system as well as providing receptors for the limited specificity shown by innate immunity [ 1- 4].
The current results align with those obtained using fetuin as a ligand in SPR that indicate this glycoprotein does not provide receptors to allow quantification of HA from all influenza viruses.
These findings suggest that rabbit B cells can be activated from the G0 stage of cell cycle to G1 by monovalent anti-Ig reagents but further cell cycle progression requires maintenance signals provided by receptor crosslinking.
Lowering the cholesterol content in liver cells could up-regulate LDL receptors, providing more receptors for taking LDL out of the bloodstream, thus lowering serum cholesterol levels and inhibiting plaque formation.
We found that oligomeric complexes of the receptor undergo ligand-mediated endocytosis when the α-factor binding site and the endocytosis signal sequences are located in different protomers, indicating that individual receptors cooperate to provide different receptor functions in trans.
In this research update, a description of the various reported receptors for GHB is provided, including GABAB receptors, certain GABAA receptor subtypes and other reported GHB receptors.
Shi, Y. et al. Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome.
This provides a receptor repertoire to respond to all pathogens that infect humans.
Transfection of SW480 cells with WT3c had the same effect, probably by providing additional receptor binding sites.
