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This information is provided in the revised manuscript.
This information is now provided in the revised Methods.
The Kd value for each protein is now provided in the revised manuscript.
These details and the Sigma product number have been provided in the revised Materials and methods under "Fly husbandry".
The detailed explanation of how to do one or two of these other analyses should be provided in the revised version.
3. C) The justification for use of kernel ridge regression is provided in the revised manuscript, please see sub-section "Predictive modelling methods".
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Indeed, in data we provide in the revised version of the work ligand binding to back filopodia can be observed as well.
Still, on the request of Reviewer, we provide, in the revised version of the manuscript, a representation of the alignment that was created by Jalview [ 91] with the use of the Taylor coloring scheme [ 92] (new Additional file 1: Figures S4b, S8 and S9 ).
While in the 1982 ACR criteria it is explicitly stated that ANA are to be determined by IIF, no details are provided either in the revised ACR or the SLICC criteria about the interpretation of cytoplasmic and mitotic patterns.
The members of the CONSORT group listed above attended the consort meetings and provided input in the revised checklist, flow diagram and/or text of this manuscript.
However, all reviewers also agreed that more context about the function of the complex should be provided in a revised version of the manuscript.
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