Recent data indicate that calcineurin inhibitors activate the thiazide-sensitive sodium chloride cotransporter, providing further rationale to test thiazides in this population.
These data provide further rationale for investigating the role of substrate stiffness in VIC remodeling within diseased and tissue engineered valves.
TGF-β appears to be a key player in this process, providing further rationale for the development of anti-cancer therapeutics that target the TGF-β pathway.
Further studies focusing on reactivity with viruses from specific clinical cohorts in which RV144 follow-up trials would be carried out might provide further rationale for the selection of specific immunogens.
Kang et al. recently demonstrated that early innate immune events were detrimental to the development of emphysema in smoke-exposed mice [13], providing further rationale for examining the impact of acute cigarette smoke exposure to H1N1 influenza antiviral responses.
In addition, special issues with the taxanes provide further rationale for application of delivery systems.
This provides further rationale to not routinely monitor bone density response to oral bisphosphonate treatment.
The results of this study provide further rationale for the continuing use of infusion bleomycin schedules in cancer patients.
