Sentence examples for provided compound from inspiring English sources

Replacement of the aldehyde of SJA6017 by an α-ketoamide provided compound 2 that was approximately equipotent with SJA6017, but it was extremely water-insoluble.

Further optimization of the P1 group led to the identification of a 4-chlorophenyltetrazole P1 analog, which when combined with further modifications to the linker and P2′ group provided compound 32 with FXIa Ki = 6.7 nM and modest oral exposure in dogs.

The most active compound 8f has shown the MES-induced seizures with ED50 value of 28.05 mg/kg and TD50 value of 561 mg/kg after intraperitoneal injection to mice, which provided compound 8f with a protective index (TD50/ED50) of 20 in the MES test.

RFY synthesized and provided compound Y27.

Deprotection of the TIPDS moiety proceeded straightforward using tetrabutylammonium fluoride (TBAF) and acetic acid and provided compound 1, the actual precursor for introducing the triphosphate group (Scheme 1A).

Displacement with a phosphite anion and then sequential N-SES and global benzyl deprotection provided compound 11 as an "elongated" phosphonate analog.

The agency has not provided compounded drugs to any other state".

Further optimization using parallel synthesis provided compounds with Ki's <50 nM.

Pegylation of a potent analog has provided compounds with good potency and good in vivo pharmacokinetic properties.

Further modifications to the methylpyrrole core provided compounds with improved properties and enhanced activity in a mouse model of multiple myeloma.

In addition, optimization of these molecules provided compounds which exhibit selectivity for NRI over the dopamine (DAT) and serotonin (SERT) reuptake transporters.