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Glucagon (GlucaGen) was provided by courtesy of Novo Nordisk.

Melanoma cell lines and useful information on the cell lines were provided by courtesy of Anja Bosserhoff.

The antibody against human ADAMTS5 was purchased from Millipore (Billerica, MA, USA) and the antibody against MMP-13 and FGFR1 neutralizing antibody were provided by courtesy of Dr. Gillian Murphy and Dr. Simon Cool, respectively.

All the basic plasmids (pUAS-tk-luc (57), pd2eGFP1 (Clontech Laboratories, Inc., Mountain View, CA, USA), pM (Clontech Laboratories, Inc., Mountain View, CA, USA) and pG3Z-K14 [ 53]) were present in house and the pSG5-VDR plasmid was provided by courtesy of Leo Pharma, Denmark.

DTIs and MIs can be estimated using one of two estimators; a kernel density estimator we implemented based on the work of [ 23] and a b-spline estimator based on the work of [ 24], implemented by Boris Hayete and provided by courtesy of the Gardner Lab of the Berkeley University.

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Biological data is a set of unrooted gene trees provided by the courtesy of Prof. James McInerney (National University of Ireland, Maynooth).

KM12L4 were provided by the courtesy of IJ Fidler, MD Anderson Cancer Center.

To evaluate the performance of our method, we test it on a large dataset provided by a local hospital, courtesy of the SiWei medical company (Shanghai, China) and SiWei Remote ECG diagnostic center.

A pMFG-HSVtk vector was provided by RIKEN BRC through the National Bio-Resource Profecthef the MEXT, Japan, by courtesy of Dr. Hirofumi Hamada, and an HSVtk cDNA was excised from it as an Nco I- BamH I fragment.

Primer sequences for the ATP6 gene were by courtesy provided by Ana Sanchis and Amparo Latorre.

The illite was provided by the Institute for Clay & Interface Mineralogy at RWTH Aachen, (courtesy of Pieter Bertier) and consisted of fine illite/muscovite with 6 to 7 wt.% quartz and no other detectable clays.

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