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Cineradiographic (X-ray film) studies of the skeletal kinematics of lung ventilation in alligators and birds provided a structural framework for our reconstruction of the pterosaurian breathing pump [26], [27].
These factors combined to yield differences in affinity that accounted for differential antibody recognition of bacterial CPS and provided a structural framework for interpreting the observed immunological data.
The crystal structures of a bacterial homologue of GlT (Gltph) in both the IF and OF states have provided a structural framework for understanding the transport mechanism of all GlTs.
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The crystal structures of the ClC channels of Escherichia coli and Salmonella typhimurium provide a structural framework for the entire family.
The structures allow a detailed rationale to be developed for the observed affinity of the PU3 class of compounds for HSP90 and also provide a structural framework for design of compounds with improved binding affinity and drug-like properties.
These findings together with previously reported data on wt and mutant p53 provide a structural framework for understanding p53 dysfunction as a result of oncogenic mutations and its rescue by suppressor mutations and for a potential drug design aimed at restoring wt activity to aberrant p53 proteins.
The models provide a structural framework for interpretation of the resulting functional analysis.
Our models provide a structural framework for interpreting experimental data and allow predictions of the TLR signal transduction process.
The data also provide a structural framework for tailoring powerful and selective M-channel modulators, including openers and blockers.
The structures of both of these domains have been determined and not only provide insights into their functional significance but also provide a structural framework for understanding cancer causing mutations [4], [5].
The N-terminal region harbors five LRR, a motif of 22 26aa defined by the consensus LxxLxLxxNxLxxLPxxL (where L can be leu, val, ile, or phe), previously shown to provide a structural framework for protein/protein interactions [10].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com