We used a replicated randomized N-of-1 design (Edgington and Onghena, 2007), which makes it possible to investigate the effects of an intervention on small groups of patients, provided sufficient assessments are made.
Two studies [ 19, 23] did not provide sufficient information for assessment of incomplete outcome data.
We therefore estimated that data from about 400 trials would provide sufficient information for assessment of associations between trial features and type of outcomes selected.
With respect to quality assessment, the least favorably ranked sub domain was that of confounding and bias (within Domain 2 - Do I trust it?); all 14 studies scored either negatively or did not provide sufficient information for assessment of one or more of the items in this sub domain.
Surgical treatment is the mainstay of endometrioma management when treatment is required, aimed at the elimination of endometriotic tissue, to provide sufficient tissue for histological assessment and to preserve a maximum amount of normal ovarian tissue (where fertility is desired and/or risk of menopause is to be avoided).
Ten qualitative studies (including the seven with no formal analysis of the qualitative data) did not provide sufficient data to allow assessment of methodological quality.
Furthermore, a large proportion of the papers did not provide sufficient detail to allow critical assessment of the quality of design or reporting.
The RACGP guideline did not provide sufficient information for AGREE II assessment.
Administrative data, which are created mainly for billing purposes, often do not provide sufficient detail for reliable quality assessment [ 3- 5].
Similarly, none of the many investigated treatments or treatment combinations may provide sufficient clinical information enabling the assessment of the safety of the suggested combination therapy in the way this is done in the standard drug development process, and we acknowledge that this standard process is justified by historical fallacies.
