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The shorter duration of administration without the need of a steroid premedication and lack of cumulative side effects with marginal cardiac toxicity provide strong argument for its choice as the control arm in future phase III trials including trastuzumab-based combinations.
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Numerous commentators provide strong arguments against Thomson's critique (Scanlon, 1975; Inness, 1992).
In summary, the association between genetic variation in the IL10 gene, cytokine production and mortality, the skewing of allele frequencies over age and environmental conditions, all provide strong arguments for selection of genetic variation inducing pro-inflammatory responses.
Second, a number of data provide strong arguments against seed contamination.
We believe that the results of our simulations provide strong arguments for rigorous dynamic modeling of drug biotransformation at the cellular level embedded in a systems biology approach.
Interestingly, cell cycle gene involvement was suggested by the authors, although their analysis of the data did not provide strong arguments for it.
These datasets provide strong arguments for the value of neoadjuvant endocrine therapy trials as a 'proving ground' to test the efficacy of new endocrine therapy approaches for breast cancer.
Our results and the data from the studies of ovine and human AA-NAT in vitro and in transfected nonpineal cells [ 29– 32] provide strong arguments against the thesis that intensity of serotonin acetylation is controlled exclusively by synthesis and degradation of AA-NAT.
The findings of KLK3 adaptive evolution and of its expanded enzymatic spectrum on top of the restricted KLK2 spectrum provide strong arguments for a significant impact of KLK3 emergence in the hydrolysis of semen coagulum and in the extensive SEMGs fragmentation as currently seen in humans.
Although the patient did not identify the insect in his garden, the chronology of his clinical history and the presence of a typical chancre at the place of the insect bite that occurred before symptoms provide strong arguments in favor of this hypothesis.
The evidence from this study showing that childhood social circumstances influence health status in older age both directly and indirectly could provide strong arguments for policy makers to focus on socio-economic conditions of families with children aiming to reduce health inequalities across the entire life course.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com