We have provided solid rationales for further clinical trials testing either examination of the bioenergetic propensity of HCC to predict the efficacy of sorafenib or activation of OXPHOS by PDK inhibitors as a measure of enhancing therapeutics efficacy of sorafenib.
This requires that the secondary provide solid coverage.
But the lack of a clear biological rationale has made it difficult to choose the proper link function and there are no epidemiological studies that could provide solid evidence to support a linear or log-linear relationship between influenza cases and hospital admissions.
These findings provide a solid rationale for tailoring antiepileptic treatments to the specific subunit composition of neurotransmitter receptors and they provide potential targets for the development of antiepileptogenic treatments.
These murine studies are encouraging and provide a solid rationale for investigations of in vitro expansion strategies and adoptive transfer of human Treg cells for therapy of T-cell mediated autoimmune diseases or transplant rejection.
In conclusion, we believe that our meta-analysis provide a solid rationale for future interventional randomized controlled trials investigating the hypothesis that statins improve the clinical outcome of infectious diseases.
Overall, these results provide a solid rationale for a future clinical translation.
