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The fracture mechanisms were analysed to provide physical justification for such anisotropic behaviour.
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Eyring's transition state theory provides physical justification for using ΔG difference instead of other comparisons between terminal ΔG values (e.g. their ratio) in estimating the terminal siRNA duplex asymmetry (Figure S1).
Does it provide physical support?
Here, we provide a strict physical justification for this hypothesis.
I am not sure what the physical justification for this amplification factor is? In the absence of providing a physical justification, I would be forced to interpret g as a fudge factor.
A physical justification of Markovian models for coupled chemical reactions has been provided by Gillespie [ 17].
A perturbative analysis of a particular solution is also performed, and some physical justification for one of the considered forms for the energy density are provided in the Appendix.
But what was the physical justification for this procedure?
based on the absolute observation values generally has no rigorous physical justification.
A physical justification for this latter expectation is rather simple to motivate.
This has much less physical justification than methods based on SH representation.
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