R-C4 - Data Management: The system shall provide methods for validation of data completeness and integrity [ 32, 34, 35 ].
To validate the methods proposed here, we selected a dataset that fit three criteria: 1) the set must be sufficiently large to provide reasonable assurance of method validation; 2) the selected set must be small enough that a researcher could usefully consider each individual result; and 3) the selected set must be composed to be of general, biological interest.
Recently the 'fit-for-purpose' approach has emerged to provide guidance on biomarker method validation (Lee et al, 2005, 2006; Tan et al, 2009).
Cross-referencing of all draft genomes against a catalogue of enzymatically active glycoside hydrolases provided a degree of method validation and was in majority agreement with our predictions.
JJZP performed the search, screening, and abstraction, and JNK provided validation (see Validation in Methods).
Human EDTA-plasma for method validation was provided by Richmond Pharmacology Ltd. (London, UK).
Method validation is aimed at providing this guarantee.
However, few of them provide effective validation methods to analyze design objects at different degrees of refinement before their actual implementation and deployment.
Although many aspects of biocurators' work depend on computation and automation, the development of new tools absolutely requires biologists and bioinformaticians to validate the methods, provide validation tests and ensure their overall usefulness for the community.
If proper method validation is carried out AAS-based methods can be used and they are cheap and easy-to-use methods which can provide correct results.
In addition to the psychometric approach usually used to validate such instruments, we have also employed psychophysical methods to provide additional validation (this dual approach is discussed further in Section S3 in the online supplementary material).
