Upon finding the missing schoolgirl's voicemail inbox to be full, The Guardian reported last night, the NOTW decided to delete messages in order to allow more to be left – which could then provide leads for stories.
They also provide leads for further structural investigations.
The structures of such interactions provide an excellent starting point for their characterization and manipulation, and can provide leads for targeted inhibitor design.
In particular, compounds that can potentiate GlyR function should provide leads for novel muscle relaxants in addition to sedative and analgesic agents.
These results document the use of receptor mimicry by a retrovirus to occlude a key neutralization target site and provide leads for the design of therapeutic strategies against HIV-1.
Ongoing studies designed to identify genetic modifiers of CF pulmonary phenotype may offer new insights into the pathophysiology of CF lung disease and provide leads for new CF therapeutic interventions.
Several of the new compounds have activities in the 3 9 μM range, and provide leads for the development of a novel class of antiparasitic drugs with improved biological and pharmacological properties.
Finally, we identified druggable fusions involving genes such as TMPRSS2, RET, FGFR3, ALK, and ESR1 in 6.0% of cases, and we predicted immunogenic peptides, suggesting that fusions may provide leads for targeted drug and immune therapy.
These results provide leads for targeting aggressive and drug resistant forms of pancreatic cancer cells.
Limitations to our analyses provide leads for further research.
It would also provide leads for experiments and drug design.
