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This data provide further rationale to combine GRN163L with other agents able to affect telomere shortening or genomic integrity to significantly expedite tumor cell killing.
These data provide further rationale for investigating the role of substrate stiffness in VIC remodeling within diseased and tissue engineered valves.
Further studies focusing on reactivity with viruses from specific clinical cohorts in which RV144 follow-up trials would be carried out might provide further rationale for the selection of specific immunogens.
In addition, special issues with the taxanes provide further rationale for application of delivery systems.
The results of this study provide further rationale for the continuing use of infusion bleomycin schedules in cancer patients.
Because the regulation and biologic function of a number of these serine proteinase inhibitors remains incompletely defined, our analyses provide further rationale for their continued study.
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This study provides further rationale for targeting Mst1r as a therapeutic strategy.
Recent data indicate that calcineurin inhibitors activate the thiazide-sensitive sodium chloride cotransporter, providing further rationale to test thiazides in this population.
TGF-β appears to be a key player in this process, providing further rationale for the development of anti-cancer therapeutics that target the TGF-β pathway.
Kang et al. recently demonstrated that early innate immune events were detrimental to the development of emphysema in smoke-exposed mice [13], providing further rationale for examining the impact of acute cigarette smoke exposure to H1N1 influenza antiviral responses.
These observations provided further rationale to examine PTEN and AR in human prostate tissues.
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