We predicted that omission of the NMHAA moiety would obviate the bound water molecules that provided complementarity with the antibody-combining site, and the conformational restriction resulting from imposition of an α-turn at the C-terminus of the peptide.
Apart from its originally designed use with collision-induced dissociation (CID) and higher-energy collisional dissociation (HCD), isobaric tagging technique could also work with electron-transfer dissociation (ETD), which provides complementarity to CID and is preferred in sequencing peptides with post-translational modifications (PTMs).
(A ) Predicted MREs were obtained from PITA (http://genie.weizmann.ac.il/pubs/mir07/mir07_prediction.html ) and their mutants were generated by mutating nucleotides providing complementarity and G-U wobble to corresponding miRNAs.
Here, computer-derived models and simulation provide great complementarity as even a sparse set of experimental constraints can largely improve the predicting power of modeling and simulation techniques.
The compound 7812 extends into this cavity and provides surface complementarity through multiple ring structures.
SMEs can provide a 'dynamic complementarity' (Rothwell and Dodgson 1991; Dodgson 2014) through flexibility and responsiveness to new market requirements and application in ways larger enterprises cannot.
Our findings provide an important complementarity to conventional GHZ-state distillation protocols (designed for GHZ-diagonal states) in theory, as well as having practical applications.
Thus, partial reversal of the peptide bonds of the backbone can result in peptides with enhanced activity compared to a parent compound, provide that the structural complementarity of both the side chains and end groups are conserved.
The two major approaches to measuring HRQOL are generic and disease-specific instruments, and the two have been compared [ 17, 18] in diabetes patients and shown to demonstrate complementarity and provide different kinds of information, with the generic ones perhaps providing more information than their disease-specific counterparts [ 19].
The results provide evidence for significant complementarities between internal R&D and R&D cooperation, but cast doubt on the complementarity of internal and contracted R&D, since a productivity effect on firms' patenting probability or sales with new products cannot be found.
