Sentence examples for provide additional interaction from inspiring English sources
Nevertheless, we had obtained very useful SAR information from screening the three OBOC libraries (Fig. 1 and Table 1): No additional amino acid is needed at the N-terminus of LXY1, but a hydrogen donor residue (or a polar residue) at the C-terminus might improve binding since it can provide additional interaction with adjacent binding pocket.
On the basis of our preliminary simulations, small modifications are feasible and may provide additional interaction with the PDZ1 domain and thereby enhance affinity.
In addition to Phe261, His283, and Asp286, residue Met285 is in the close proximity to G34 and may provide additional interaction to fine-tune the anticodon recognition by MjTyrRS.
The novel (K/R RRW motif in the isoform-specific region of the holometabolous insect EcR-B1 isoform might provide additional interaction sites for co-regulatory proteins and mediate the holometabolous insect-specific regulation of the B1 isoform-specific AF-1 transactivation function.
Following along the lines of the acryoylcarbamate inhibitor of Thorsen et al., we can envision addition of substitutions to the benzene ring that would provide additional interactions within the peptide binding groove.
Thus, as SNF does not interact with SXL directly, it is questionable whether SNF could provide additional interactions between SXL and U1 snRNP [20].
Computational analysis suggested structural alterations that could provide additional interactions with RT and thus improve inhibitory potency.
Consistently with this, molecular modeling study revealed that the triazole part of 39 could provide additional interactions to the S3′ subsite of renin active site.
The model suggests that compounds with appropriate substitutions at C4 or C5 of the benzene ring might exist that provide additional interactions with D339 and thus increase the affinity of the compound to PHD HD1.
The sulfonate moiety provides additional interaction with Lys15′ and a water-mediated hydrogen bond with Thr119′.
It has also been proposed that SNF regulates Sxl splicing by providing additional interactions between SXL and U1 snRNP, which are critical when SXL levels are low [20].
