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Ribavirin may provide a structural lead for design of more selective inhibitors of Tc-SAHH as potential anti-parasitic drugs.
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This work also provides a structural lead for the design of new non-ATP-competitive FGFR1 inhibitors.
These observations provide a structural milestone for understanding multidrug resistance in pathogenic Gram-negative bacteria, and may also lead to the design of new antibacterial drugs.
The sites correlate with extensive electrophysiological data and provide a structural basis for understanding rectification.
Bone scaffolds provide a structural support for tissue development.
To provide a structural explanation for enhanced binding for pSer670 and pSer676, we did structural modeling by replacing the aspartate sidechains with phosphoserine.
Such extensive transcriptions may provide a structural explanation for Hox clustering.
The models provide a structural framework for interpretation of the resulting functional analysis.
This may provide a structural basis for an active site.
Our data provide a structural rationale for these observations.
The authors make a number of suggestions to provide a structural basis for previous biochemical observations.
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