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Here we report the crystal structure of WbnH and provide a structural foundation for explorations of the molecular mechanism by which WbnH adopts acceptors and substrates.
These data also provide a structural foundation for the future design of small molecules that function as inhibitors of ArgE and may potentially function as a new class of antibiotics.
The avian eggshell membranes surround the egg white and provide a structural foundation for calcification of the eggshell which is essential for avian reproduction; moreover, it is also a natural biomaterial with many potential industrial and biomedical applications.
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This information advances our knowledge in AKT1 structure and regulation, thereby providing a structural foundation for interpreting the effects of different classes of AKT inhibitors and designing selective ones.
Numerous culture-based studies show that, in addition to providing a structural foundation for cells, ECM components convey contextual information through cellular adhesion molecules, such as integrins, that transmit external ECM-derived signals to the cell interior.
Our combined findings provide a structural foundation on which to build our growing mechanistic understanding of the DNA polymerases that replicate the genome of eukaryotic organisms.
We conclude that ∼40 kb is sufficient to establish a structural foundation for kinetochore assembly in chicken cells.
As the many roles for plant cell wall degrading enzymes increase, so does the need for rapid high-quality structure determination to provide a sound structural foundation for understanding mechanism and specificity, and for future protein engineering strategies.
We have provided a quantitative structural foundation for earlier biomechanical findings in pulmonary leaflets and the basis for validation of theoretical assumptions still lacking the support of experimental evidence in both conduits.
Rib is also ingested as a supplement for cardiac energetic metabolism for instance the patients with stable coronary artery disease as the sugar provides the structural foundation for ATP.
Our cataloging and structural analyses provide a comprehensive foundation for experimentally dissecting fungal aaRSs that may enable development of new anti-fungal agents.
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