Sentence examples for provide a structural basis for from inspiring English sources
The structural information achieved confirm the role of EfTS as an enzyme involved in the folate pool system and provide a structural basis for structure-based drug design.
A docking study of compound 9d was performed to elucidate its possible binding modes and to provide a structural basis for further structure-guided design of PAK4 inhibitors.
To provide a structural basis for these observations, we determined the structure of wt RB69pol with 3DA at position n – 1 of the template strand.
The present structure and the homology model of archaeal GINS will provide a structural basis for clarification of the GINS functions, including the formation of the CMG unwindosome complex.
To provide a structural basis for these nearest neighbor effects, we determined high-resolution structures of tm RB69pol ternary complexes that had the highest and lowest incorporation efficiencies for each incoming dNTP.
To provide a structural basis for enhancing the specificity of these benzoxaborole antifungals, we determined the structure at 2.2 Å resolution of the C. albicans editing domain in complex with a related compound, AN3018 (6- ethylamino -5-fluorobenzo[c][1,2]oxaborol-1 3H -ol), using AMP as a surrogate for the 3′ adenosine of tRNAleu.
This complex structure provides a structural basis for the observed micromolar inhibition towards UGM.
The structure provides a structural basis for understanding the complex assembly of mTORC1 and the regulatory mechanism of mTORC1 by its binding partners and those yet to be identified.
Our structure provides a structural basis for the study of the pathogenesis of VHL disease and rationale for the design of novel compounds that may modulate cullin-substrate receptor interactions.
Moreover, the AM1 complex crystal structure provides a structural basis for designing the next generation of ABA-mimicking small molecules.
However, while the TM287/288 structure provides a structural basis for asymmetric nucleotide binding, it does not elucidate the mechanistic role of such an intermediate in the transport cycle in the presence of substrate and under conditions of ATP turnover.
