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Each follicle will not only harbor the oocyte, but also provide a microenvironment of support cells necessary for the development of the oocyte, the synthesis of the DNA and RNA stores that the early embryo will need for development postfertilization, and the production of the multilayered eggshell.
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Thus, development of a bioactive scaffold to provide a microenvironment to support function and promote cell adhesion, growth and proliferation is one of the most emergent challenges of recent decades 25.
Our novel IUCS was designed to circumvent many of the shortcomings inherent to the in vitro systems and appears to provide a microenvironment that supports equal or superior preimplantation embryo development, as suggested by the present data.
In this way, the exon-containing lariat may provide a microenvironment for the splicing of circular RNA.
Thus, the stroma of ovarian tumors histologically resembles that of normal adult ovary, and can likely provide a microenvironment that promotes the development of primary and metastatic tumors.
HSC niche consists of supporting cells such as osteoblasts and other stromal cells that provide a microenvironment for HSCs, as well as molecules produced by these cells.
FL-HSCs undergo a high frequency of cycling and self-renewal until E14.5, contrasting sharply to the quiescent and limited self-renewal of BM-HSCs[4].This suggests that the FL provides a microenvironment that is more conducive to supporting HSCs.
DSP not only provided a microenvironment for the survival of MSC, but also promoted the angiogenesis after transplantation.
The electropolymerized film of cysteine provides a microenvironment for the enzymatic reaction while the metallic Cu acts as an active center with catalytic function.
A full complement of hepatic cells provides a microenvironment that explores more than co-culture conditions.
Rather, Matrigel may be providing a microenvironment that activates rare bipotent progenitor cells capable of regeneration, albeit limited.
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CEO of Professional Science Editing for Scientists @ prosciediting.com