Sentence examples for provide a mechanistic framework to from inspiring English sources

Our results provide a mechanistic framework to understand the catalytic and non-catalytic functions of mammalian TG2 in physiology and disease.

Such integrative approaches could potentially provide a mechanistic framework to predict pathways and proteins associated with a particular cellular state [ 118] that would likely benefit from more omics datasets.

These empirical findings provide a mechanistic framework to explain the clinical observations that HCC patients with high levels of KDM5C in tissue samples have more chance of distant metastasis, a significantly shorter overall and disease-free survival.

The identification of gene signature networks that are stress activated provides a mechanistic framework to characterise the multifaceted nature of weaning stress adaptation in beef calves.

This study has identified regulatory gene networks that are stress activated, and may be modulated by glucocorticoids in leukocytes, and provides a mechanistic framework to characterise the multifaceted nature of weaning stress adaptation in beef calves.

A detailed analysis on protein expression levels for these peroxisomal proteins revealed a remarkable negative correlation between binding affinities and expression levels of cargo proteins, thus providing a mechanistic framework to generating a uniform population of Pex5p-cargo complexes necessary for proper peroxisomal biogenesis [ 28].

We have also used a kinetic model of GPCR homodimerization to provide a mechanistic framework within which to quantify the allosteric interactions across the dimeric interface of GPCRs in terms of affinity and cooperativity.

Quantification of probe-dependent cooperativity factors can provide a mechanistic framework within which to understand the influence of dimerization on ligand-GPCR interactions and, as such, develop structure-activity relationships for ligands interacting across a dimer interface.

These results provide a mechanistic framework of substrate-assisted catalysis of both factor VIIa and factor IXa.

Basic research studies, including the characterization of genetically engineered mice, provide a mechanistic framework for understanding how mutations create the clinical characteristics observed in patients.

These studies will generally provide a mechanistic framework for the flexibility of the translational machinery and establish the boundaries of the unnatural translation.