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Continued research on the regulation of asymmetric and symmetric self-renewal division of CSCs will provide a means to target CSCs in various tumors.
Through these effects, photoactivation of sequestered sunitinib may additionally provide a means to target drug-resistant sub-populations of cells, as it has been shown that there is a significant increase in the accumulation of lysosomally sequestered sunitinib in sunitinib-resistant cell cultures as compared with non-resistant parent cell cultures 24 h after incubation with sunitinib.
Understanding the miRNAs that are involved in gene regulation and others that are 'effectors' in the downstream signalling will provide an opportunity to interrogate these miRNAs to develop biomarkers for the gene in question, and will also provide a means to target the biological effects of the gene(s) of interest and certain undruggable molecules.
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Tethering of PDE4D to the β1AR provides a means to target cAMP hydrolytic activity in the vicinity of the unoccupied receptor, thus, preventing a local increase in cAMP under basal conditions.
Studies in model organisms have gained more and more importance in the quest for identifying disease gene candidates because they provide a means to specifically target genes and observe the consequences on an organism scale.
In the context of antibody drug conjugates (ADCs), noncleavable linkers provide a means to deliver cytotoxic small molecules to cell targets while reducing systemic toxicity caused by nontargeted release of the free drug.
Further parsing of these miRNAs and their targets may provide a means to drive ES cell differentiation along specific lineages and to facilitate conversion of somatic cells into iPS cells.
The resulting cfu counts provide a means to assess the relative reactivity of a human antibody repertoire towards the two target proteins.
Thus, interfering with VEGF or VEGFR2 provides a means to selectively target tumor endothelium.
Adoptive T cell immunotherapy is an evolving technology with the potential of providing a means to safely and effectively target tumor cells for destruction.
The application of microarrays thus provides a means to identify possible molecular targets of RF electromagnetic fields in plants.
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