Especially the peak intensity in the region approximately 310 nm decreases dramatically after 48 h, providing a first hint that some functional groups in GO may decrease [24].
This fact is quite remarkable since it suggests a coherency between manchette formation and posterior localization of Sun3 and, moreover, provides a first hint for a putative involvement of Sun3 in nucleo-cytoskeletal linkage.
As the levels of 1183 mRNA were decreased at elevated levels of RNA-2571 (Fig 2B), these pilot studies provided a first hint for antisense regulation in a hyperthermophile.
Thus, our study provides a first hint to the intriguing possibility of the GlgE pathway being organized as a multicatalytic machinery that controls the flow of pathway intermediates by complexation between pathway enzymes.
The discovery that some loci, notably imprinted ones, escape reprogramming in the early embryo, provided a first hint regarding the mechanism behind epigenetic inheritance as this brought into question the rigidity of epigenetic erasure between generations as a principle.
Curiously enough, however, the Babler and Dannemiller study the very study that seemed to have established velocity ratio as the perceptual variable used to judge acceleration also provided a first hint that this variable does not fully fit the bill.
The observation that HCCs are under apparent selection pressure to recruit MSCs into the tumor environment already provides a first hint of the importance of these cells for HCC growth.
Besides that, only one earlier study dealt with a signaling event in H. jecorina: Mach and coworkers [ 14] showed that calmodulin-antagonists interfere with xylanase formation and secretion and thereby provided a first hint as to the significance of Ca2+ signaling in this fungus.
Grönholm et al. [ 83] provided a first functional hint for neuronally expressed merlin in the CNS.
