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I appreciate that in the absence of experimental data, these types of modelling study are useful, but there is a danger of them becoming accepted as reality, particularly if determining the high-resolution structure of the complex proves intractable.
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And like all such problems, this one, too, has proved intractable.
Certain problems are proving intractable - climate change; an ageing population; long-term chronic diseases; economic inequality.
To hasten the villagers' departure, the government proved intractable to pleas for electricity and running water.
But even if he manages it, the court may prove intractable.
Mr. Obama correctly noted that both Israeli and Palestinian leaders had proven intractable.
German bombers began their attack in August 1940, but the British proved intractable.
Tying it to the meridian, or any other natural benchmark, proved intractable.
His other priority, reviving the Mideast talks, has proved intractable for far longer.
But despite a number of smoke abatement laws, this problem also proved intractable even for the resourceful Victorians.
This makes it more worthwhile to research diseases that are rare, and those that have so far proved intractable.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com