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We tested the premise with Lactate: Creatinine ratio (L: C ratio)- a proven marker of asphyxia.
It has been shown that the waist circumference is a proven marker of higher total mortality risk as well as of a cardiovascular risk.
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Taken together, the dramatic up-regulation of RAB25 and down-regulation of TUSC3 in RIα cells appears to faithfully mimic the activity profiles of proven markers of ovarian cancer clinical progression.
For this purpose, tumour growth and metastatic behaviour of six different human melanoma cell lines subcutaneously xenografted into scid mice was analysed and correlated with the expression of proven markers of metastasis in clinical studies (Thies et al, 2001, 2002a, 2002b, 2006).
Demonstrating antiatherothrombotic properties of dipeptidyl peptidase-4 inhibitors on proven markers is of substantial clinical significance.
sVCAM-1 is also a well-proven marker of endothelial dysfunction and has been associated with atherosclerosis [ 51] and small-vessel disease [ 52].
This is largely due to the lack of clinically proven molecular markers of prostate cancer progression.
Bone metabolism with P-OPG measurements may prove important markers of vascular calcification.
Evaluation of urinary TGF-β1 levels may be proved a useful marker of clinical outcome in patients with crescentic nephritis.
We can speculate that bifurcated melatonin excretion could prove a valuable marker of a bifurcated antiphase orientation of human SCN neuronal populations, and perhaps this antiphase SCN organization is the specific circadian disorder of mania.
Total, but not active, plasma TGF-β was elevated pre-treatment and remained at the same levels at all periods evaluated, and differences were not significant (Fig. 3B), proving un unreliable marker of cure.
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