Exact(3)
In addition, no mutations in SPAG8 were found in an ALS patient from a family with proven linkage to the 9p13.2 21.3 locus (19).
Index patients from the other unexplained families and from an ALS pedigree with proven linkage to 9p (19) were used for validating the results obtained.
Human papilloma virus (HPV), Epstein Barr virus (EBV) and the polyoma viruses JCV and BKV represent viruses with proven linkage to different human cancers and have been traced in prostate cancer tissues (Grinstein et al, 2002; Zambrano et al, 2002).
Similar(57)
The literature proved to be rich in discussion of the elements of quality pre-service education but underdeveloped in discussion of proven linkages between PSE and quality healthcare service delivery, which is the intended outcome of competency-based education.
The families are therefore theoretically powerful enough to prove linkage under a recessive model and powerful enough to provide a good indication of the presence of linkage under a dominant model.
Building up the pyramid, the work was based less on the victim testimony of earlier trials than facing down the difficulties of direct government obstruction of our efforts...the trials become more sterile and lose the victims' voice, because the trials at the top, with the likes of Karadzic, are all about proving linkages, with the atrocities already established".
This means typing methods can only be used to support epidemiological data and should/can never be used to prove a linkage by themselves.
Genetic causation can only be proven by either linkage (segregation within a family) or association (more frequent occurrence in affected individuals than in controls).
In several cases of hot tub lung, the source of infection has been proven by genotypic linkage by multilocus enzyme electrophoresis and restriction fragment length polymorphism analysis of the NTM isolated from the source and from the human specimen (Kahana et al. 1997; Lumb et al. 2004; Mangione et al. 2001; Marras et al. 2005).
Extensive efforts to identify genes by linkage mapping in families has proven relatively unproductive, with linkage demonstrated at genomewide significant levels to only one region (chromosome 16q (LOD score 4.7)) [ 9].
25 The genetic heterogeneity of LQTS was ultimately proven in 1994 when linkage analysis identified loci on chromosomes 7 and 3. 26 This led to classification of LQTS into subtypes based on genetic loci.
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