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Ordinal regression and multiclass pattern classification techniques are attractive propositions, to examine discrimination of novel compounds against those with of known efficacy (or proven lack of efficacy), differing mechanisms of action or examination of dose-response rates [Doyle et al., 2013; Marquand et al., 2012].
Case in point: several producers who declined to invest in "Prince of Broadway," some of whom have made money from Prince shows, said in interviews that the musical would never turn a profit with its budget, given the proven lack of box office heat for retrospectives, including "Sondheim on Sondheim" in 2010 and even the 1989 Tony winner for best musical, "Jerome Robbins' Broadway".
Self-treatment of cancer with cesium chloride, despite proven lack of efficacy, continues to produce serious adverse effects.
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Under the Sexual Offences Act 2003 it is an offence to engage in any sexual activity with a child under the age of 16, and the prosecution need not prove lack of consent.
This includes a hardship letter documenting why he or she can no longer pay the mortgage — kind of like a co-op board package in reverse, this time to prove lack of resources.
Application of the brittleness indices to the tested rock specimens clearly demonstrated that the developed energy-based expression is able to rigorously capture the relative brittleness sequences of lithofacies and evolution trends under application of confinement, whereas further proved lack of either sufficient physical basis or appropriate formulation strategy in the existing indices.
For instance, it presents on ten pages with half-page color plots trivial properties of the five hexane isomers, or it uses another half-page plot in order to prove lack of correlation, and fails to convey the more general and comprehensive aspects covered by the chapter's title.
But "absence of evidence is not evidence of absence"—to prove lack of Sanofi support would require much more than a Google search.
In our exploratory BP categorical analyses, lack of statistical significance did not prove lack of risk.
However, there is no reliable metric to conclusively prove lack of druggability.
Therefore, deviation from RDA indicates interaction, but satisfying RDA does not prove lack of interaction.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com