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We expect that the HMR and MM developed for DelpHi is transferable into routine care once it has proven its efficacy.
Thalidomide has proven its efficacy in refractory cutaneous lupus disease, although it is not exempt from significant side effects and frequent relapses after withdrawal.
OnabotulinumtoxinA has proven its efficacy in reducing the number of headache days in chronic migraine (CM) patients.
Cold plasma has proven its efficacy in inactivating various pathogenic and spoilage organisms found in fruit juices.
Modified Vaccinia Ankara (MVA) has proven its efficacy as a recombinant vector vaccine for numerous pathogens including influenza virus.
Cognitive remediation is a cost-effective tool well accepted by patients and caregivers that has proven its efficacy for treating cognitive impairments in several disorders such as schizophrenia.
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Dialectic-Behavioral Therapy (DBT) is another psychotherapeutic approach that has proved its efficacy in BED; it is more focused on emotion regulation and stress tolerance than CBT [ 43].
It has already proved its efficacy in refractory kidney cancer and unresectable hepatocellular carcinoma (Llovet et al, 2008; Escudier et al, 2009).
Thus far, the PEG-LysNH2 has demonstrated to be adherent to ex-vivo tissues, resistant and easily applied, but it has yet to prove its efficacy in controlling active hemorrhage in in-vivo models of hemorrhage.
30– 32 Among them, sunitinib has proved its efficacy with a median PFS of 6 8 months, and it is approved in second-line treatment.
The difficulty of proving its efficacy is clearly one of the biggest stumbling blocks.
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