Biomarkers complement other clinical information by proving quantitative data regarding a pathophysiological mechanism that can be used for the early diagnosis of a specific disease, to monitor and guide treatment, and to predict the risk of death or other adverse events.
It proved difficult to obtain reliable data regarding the availability and use of commonly used drugs in many countries.
While we believe the reported haemoglobin changes are due to GI blood loss, we have no data regarding occult blood loss to prove this is true.
The randomized clinical trial, long the gold standard of medical research, supposedly provides the most reliable data regarding which drugs, devices and procedures prove effective on real patients and which don't.
We believe that this model, in which multiple core biopsies are taken and frozen, will prove extremely valuable for future studies, in addition to providing data regarding resistance to taxotere and epirubicin in this setting.
Although Tdap booster dose 10 years later the initial booster has been proven to be equally immunogenic and well tolerated [ 77], there is currently paucity of data regarding the incidence of local reactions after repeated immunizations in adults.
The major limitation of our study was that data regarding MRSA colonization of the farm are missing, so cattle-to-human transmission cannot be proven.
There is limited data regarding the prognostic role of HER-3 and HER-4 in human cancer and these prove to be controversial.
The mathematical model should prove extremely useful in both minimizing the number of animals that have to be sacrificed to obtain statistically significant data regarding the time course of the disease, and in rationalizing inter-animal differences.
Newspaper data is not impartial or proven and our study strongly suggests that there are contextual, including possibly cultural and political, factors that profoundly affect what and how data regarding fatalities in the Iraq War are being presented.
Although current data regarding self-medication with phyto-oestrogens by breast cancer patients remain controversial, the published literature does imply that these compounds may prove to be promising agents for future use in cancer therapy.
