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Twenty-one patients had biopsy proven active LN, 15 patients had a history of LN without current activity, and 33 patients had non-renal SLE.
Stress-assisted grain boundary migration is a mechanism that has proven active in polycrystals but that relies on a limited number of models.
Our recently designed A199S/F227A/S287G/A328 W/Y332G mutant of human BChE has a considerably improved catalytic efficiency against -cocaine and has been proven active in vivo.
Our more recently designed A199S/F227A/S287G/A328W/Y332G mutant of human BChE, denoted as cocaine hydrolase-3 (Cochas, has a considerably improved catalytic efficiency against cocaine and has been proven active in blocking cocaine-induced toxicity and physiological effects.
PABA/NO has proven active in several cancer models in vitro and in vivo, but its tendency to be metabolized via a variety of pathways, some that generate inactive metabolites and hydrolysis products, limits its potential as a drug.
Trials designed to show noninferiority require an appropriate reference population, a proven active control and dose, an appropriate margin of noninferiority that is clinically relevant and statistically justifiable, a high level of adherence to treatment, and adequate statistical power to reliably conclude that a treatment is truly noninferior and therefore effective.
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Compounds 15, 20, 21 and 30 showed considerable activity against the Gram-positive bacteria Staphylococcus aureus while 24 and 30 proved active against Bacillus subtilis with a magnitude of potency comparable to the broad spectrum antibiotic Ciprofloxacin.
The researchers said their synthetic version, called a beta-peptide, proved active against several drug-resistant bacteria, including strains of vancomycin-resistant enterococcus and methicillin-resistant staphylococcus.
Unlike Kentucky, which passed its Racial Justice Act in 1998, inmates can use statistical evidence on their behalf; they do not need to prove active, intentional discrimination.
"We got really lucky," Carroll says, as all three proved active at this time.
Six of them (1 2, 4 6 and 9) proved active as antimicrobials.
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CEO of Professional Science Editing for Scientists @ prosciediting.com