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Gallows, though, proved too harsh.
"Even a century ago people were speaking of Siberia as the land of the future," Thubron says, "but despite its vast western oil and gas deposits, and the mineral and lumber riches of its east, Siberia has proved too harsh, too guarded, too inaccessible, to comply".
The shift in concentrations originated from the earlier observation, that in wild type material 10 mg · L-1 kanamycin still allowed escapes up to a level of 17% after four weeks (Additional file 2), while the consistently high selective pressure of 25 mg · L-1 kanamycin proved too harsh as only a very limited number of transformants could be obtained in this way.
Similar(57)
This is the song that much of the tail end of the crowd have come to see, but Glass's voice proves too harsh for the melancholic modern ballad, and her timing is off, prompting many to leave before the song ends.
The report proved too optimistic.
Football proved too strong.
Hitler proved too impatient.
That may prove too late.
That may prove too pessimistic.
The previous prime minister, who was also installed after a military coup, had proved to be too harsh even for army tastes.
Vortexing was implemented throughout the protocol to help break clumps, because sonication proved to be too harsh to permit consistent recovery of signal from 5A mutants.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com