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Vorinostat in combination with lenalidomide and dexamethasone proved tolerable with appropriate supportive care, with encouraging activity observed.
Consolidation chemotherapy proved tolerable in our study and the majority (90.5%) of patients who started consolidation chemotherapy completed 4 cycles of consolidation chemotherapy, as scheduled.
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Can any of the traditional levers prove tolerable?
If true, soft chow may prove more tolerable than hard chow, given the lack of enamel.
Alternate dosing schedules for topotecan/cisplatin, or the substitution of carboplatin for cisplatin, might prove more tolerable.
Nine patients were treated in this last cohort, which was twice expanded to further assess feasibility beyond cycle 1 after proving just tolerable in the terms described in the protocol.
In terms of toxicity, the biweekly regimen also proved to be tolerable.
The biweekly administration of cetuximab and irinotecan proved to be tolerable.
As well as providing optimal blood pumping, this proved much more tolerable to the user, and consumed substantially less power.
In conclusion, dexrazoxane proved highly efficacious and tolerable in the management of accidental anthracycline extravasation.
Long-acting risperidone proved effective, safe, and tolerable in a large, 12-week randomized, controlled trial in younger adults with schizophrenia.
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CEO of Professional Science Editing for Scientists @ prosciediting.com