Sentence examples for proved problematic in that from inspiring English sources

While treatment of fibroblasts derived from these mice with 4-hydroxy-tamoxifen could be used to generate talin1 null cells, the system proved problematic in that talin2 was rapidly upregulated (Fig. S1A), and the cells were still able to assemble paxillin-containing FAs (Fig. S1B).

Then beat in the eggs, one at a time (with most recipes, I've found that you can add the eggs all together, but that proved problematic in a couple of instances, so I think it's just safer to do it this way).

The contract also repeats the "cost plus" arrangement that has proved problematic in the past.

Yet the arrangement avoided the mismatch between power and office that has proved problematic in China.

Moreover, this hypothesis most adequately explains the anatomical details that have proved problematic in other hypotheses, such as the structure and carriage of the neck and skull and relatively small feet.

That has proved problematic in this America's Cup, now the longest in history at 19 days, in part because of numerous postponements.

But that formulation has proved problematic in an economic downturn.

Later that year came Whore, about the travails of a prostitute, whose very title proved problematic in the US.

His stance immediately proved problematic in a city heavily in favor of abortion rights.

This last feature proved problematic in the extreme conditions of the Eastern Front.

The use of external providers proved problematic in several ways.