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The hot antipasto proved markedly better with a more interesting variety of eggplant rollatini, clams, mushrooms and shrimp.
Clinical results have proved markedly variable.
Likewise the CsAres culture proved markedly less sensitive to both DEB025 and CsA (EC50: 0.46±0.26 µM for DEB025 and 3.77±0.63 µM for CsA).
The assay proved markedly more sensitive to PAD2 activity than PAD4 activity, in that approximately 150 times more in-house rhPAD4 was required to achieve an extent of fibrinogen citrullination comparable to that catalysed by in-house rhPAD2.
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The 5-arylidene moiety of acids 4 proved to markedly influence the potency of these inhibitors.
The results demonstrated that compounds bearing a biphenyl moiety were proved to markedly influence the potency of these inhibitors.
In an experimental setting, the newly developed guided freehand technique for distal interlocking has proven to markedly reduce radiation exposure when compared to the conventional freehand technique.
Nonetheless, moderate weight loss in obese subjects has been proven to markedly decrease the incidence of diabetes, lower blood pressure, improve lipid profile and decrease mortality [ 9- 13].
The augmented cGMP production consequently reinforced the impaired PKG activity (proven by markedly increased myocardial p-VASP/VASP ratio) that further contributed to the cardioprotective effects of cinaciguat in DM.
Early in his tenure, Kennedy proved to be markedly conservative.
Lp-PLA2 activity proved to be markedly reduced in vivo when the enzyme is bound to HDL [8], and this is in line with our observation that aβ2GPI IgG+ patients disclosed higher PAF-AH and lesser HDL than BDs.
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