The needle-in-a-haystack search for genes linked to disease may prove less difficult than many scientists feared.
However, since the downstream transcriptional effects of the GHR-KO mutation are much less extensive than those of other long-lived models, understanding how this mutation contributes to longevity extension may prove less difficult.
It proved no less difficult to illustrate the more scandalous moments in Nijinsky's life, not least the near-riot that erupted at the premiere of Nijinsky's monumental "Sacre du Printemps," set to music by Stravinsky, at the Theatre des Champs-Elysees on May 29 , 1913
In comparison with this short-term glucose variability, it has proven far less difficult to show an association between HbA1c variability and microvascular risk (25).
Revlimid, which was developed by Celgene's chemists using Thalomid as a starting point, has proved more effective and less difficult to take, and has gained an even bigger share of the market.
Pigs and poultry were raised, but goats and sheep quickly became the most common livestock since they were less difficult to raise and proved to be successful providers of meat, wool and milk (usually in the form of cheese).
Such tests have proved less useful, since it can be difficult to agree on the correct response to emotional questions.
Even after he substituted a motor-oil smell formulated from slightly less explosive chemicals, it proved very difficult to get the odor to last long enough at a low enough level.
Locations proved more difficult to detect, with less than five and two false negatives per 100,000 words in the gold standard and test corpora respectively.
But he added that the tale about a misdiagnosed woman in a north London mental hospital would prove "much less difficult than at first it seems" to those who stuck with it.
