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Disarmament efforts have proved extremely difficult in Afghanistan, where many militiamen simply bury their guns for another day.
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Though the mastery of such systems is highly desirable, it has proven extremely difficult in the past, with several failures.
Unfortunately, ideal prospective data collection by designated study personnel proves extremely difficult in a developing country with limited resources.
While this may prove extremely difficult in species with high early life mortalities and special larval food requirements (e.g., many tropical reef fishes), it has also led to a bias in literature towards traits that are expressed relatively early during ontogeny (larval and juvenile stages) and thus require relatively short rearing protocols (weeks to months).
In this context it is sobering to reflect that, despite the compelling case for defective insulin receptor function in the patients studied, and the wealth of understanding of insulin receptor function, it has proved extremely difficult to demonstrate a defect in insulin signalling in vitro commensurate with the clinical severity of the phenotype.
Nevertheless, it proved extremely difficult for that model to solve problems in practice.
It proved extremely difficult to contact non-attenders to take part in the study.
"We knew the situation when we arrived and we tried our best to get the results to stay in the First Division but it proved extremely difficult".
A confidential Foreign Office briefing in 2007 mendaciously concluded that "it has proved extremely difficult to disentangle the truth" about the Armenian genocide.
Year two, especially the beginning, proved extremely difficult because the shock wore off and reality began to sink in.
Identification of the molecular pathway(s) from mutation to clinical symptoms in the dominantly inherited neurodegenerative diseases has proved extremely difficult.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com