Sentence examples for proved extremely difficult due from inspiring English sources

Linkage studies for complex disease proved extremely difficult due to a lack of sufficient genomic resolution to identify disease-associated loci using microsatellite markers and inadequate power to detect an association, largely due to the significant locus heterogeneity that characterizes common disease (John et al. 2004; Altmuller et al. 2001; Xiong and Guo 1998).

Direct methods of entropy estimation based on the computation of block probabilities have proved extremely difficult to apply to linguistic sequences due to the exponential explosion in the number of parameters to estimate from finite data.

Clear, colourless glass proved extremely difficult to achieve, however.

"But when this opportunity arose it proved extremely difficult to ignore.

Disarmament efforts have proved extremely difficult in Afghanistan, where many militiamen simply bury their guns for another day.

After the 90s black TV host Arsenio Hall, it proved extremely difficult for an African-American to host.

For a fiercely independent freelancer, adapting to the strict military regime at Headley Court proved extremely difficult.

Implementing the deal proved extremely difficult and the talks stalled in April 2009.

These arguments have often proved extremely difficult to resolve, because the complexity and large size of enzymes makes experimental analysis very difficult.

The undertaking proved extremely difficult, given the scant historical record of even the most significant artists.

Using the law to win convictions has also proved extremely difficult.