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The process had proved difficult to study, because natural slabs of sandstone erode over millions of years.
To complicate matters, the aphid's life-cycle proved difficult to study, as its lifespan differed from Europe to America.
However, they have proved difficult to study via conventional cultivation methods because of their slow proliferation rate and sensitivity to variations in their environments.
However, the processes underlying tissue renewal and the mechanisms that govern their coordination have proved difficult to study in the human gut.
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Appendiceal cancer is a rare disease that has proven difficult to study in prospective trials.
However, microbial communities have proven difficult to study due to a lack of suitable experimental and computational tools.
This process has proven difficult to study experimentally, and complete descriptions of how the cell couples surface membrane and intracellular signal transduction proteins to achieve both stable and sensitive intracellular calcium release are still lacking.
Although it is a relatively short protein, E6 has proven difficult to study due to the inability of the protein to be isolated in a native, soluble form.
Given the significant role of carcinogen exposure in these tumours, it proves difficult to study host factors related to cancer risk (Proia et al, 2006).
The physical properties of bent-core nematic materials have proven difficult to study, but patterns are emerging regarding their optical and dielectric properties.
Known about for over a century and still poorly understood, the lag phase has proven difficult to study due to the low density and low metabolic activity of bacteria during this phase.
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