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We sequenced and assembled a new mt-genome for Paraplea frontalis (Fieber, 1844), except for small portions of 12S rRNA gene and the control region (polynucleotide sequences in these two regions proved difficult to resolve with certainty).
A major focus of the ATOL plastid genome sequencing project is the use of whole-chloroplast genome sequence data to determine the evolutionary relationships among the basal lineages of eudicots, which have hitherto proved difficult to resolve [ 23].
Although it has proved possible to optimise the compound in terms of potency and to some extent at least the pharmacokinetic parameters, we have reached a biological issue which has proved difficult to resolve in the absence of knowledge of the cidal target.
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A key issue that has proven difficult to resolve has been balancing Macedonian nationals' commitment to the preservation of a Macedonian state with Albanians' demands for the full rights of citizenship.
As happened when the House debated and ultimately passed its American Health Care Act in May, the core disputes between the more conservative wing of the GOP conference and "moderate" lawmakers are proving difficult to resolve.
Basal mammalian divergences have proven difficult to resolve, despite the use of large amount of nuclear sequences.
Relationships between liverworts, mosses hornworts and vascular plants have proven difficult to resolve, and as such it is not clear which bryophyte lineage is the sister group to all other land plants and which is the sister to vascular plants.
Although it has proven difficult to resolve the rapid radiation of crested newts, by employing full mitochondrial DNA sequence data we now have a precise estimate of the chronology of branching events.
Relationships among acalyptrate families have proven difficult to resolve, but in several analyses the Tephritidae and Diopsidae are closely related and share a common ancestor with Drosophila no more than 76 MYA [ 37, 38].
Rat (Erlinge et al., 1998) and human (Wang et al., 2002) vascular smooth muscle cells express several subtypes of P2Y receptors, but with the limited range of selective ligands available it has proven difficult to resolve fully the contributions of each to functional responses.
Neutrality proved difficult to maintain, though.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com