Sentence examples for proved difficult to purify from inspiring English sources

Unlike the GKS protein, Irga6, for which a crystal structure is available [17], the GMS subfamily proteins have proved difficult to purify without tags and little is known of their structural or biochemical properties.

F-BAR domains containing these mutations proved difficult to purify; however, full-length Imp2-Lipid-4A, -5A, and -7A were readily purified.

We also obtained very similar zymogram data for an untagged version of the SaFEN protein, but it proved difficult to purify without the affinity tag, unlike the untagged T5FEN and ExoIX (results not shown).

Previous biophysical analysis of the SAS-5/SAS-6 interaction was performed using relatively short C-terminal SAS-5 peptides (Qiao et al., 2012; Hilbert et al., 2013), as full-length SAS-5 proved difficult to purify.

The microbe, which has yet to be successfully cultured in vitro, has proven difficult to purify from necropsy tissues.

But it has proven difficult to purify and image them; so far, the best researchers had produced was a fuzzy electron-microscopy picture of what looked like a flat string of beads.

Genocide has proved difficult to prosecute.

The effect proved difficult to measure.

Yet reform proved difficult to implement.

The furlough plan proved difficult to enforce.

The advice proved difficult to follow.