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Regarding autoimmune diseases in general, and Sjögren's syndrome (SS) in particular, verifying and expanding such models is desirable, because it has proved difficult to extrapolate findings to existing models that were often developed in different contexts [ 1- 3].
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It may thus prove difficult to extrapolate our results to other centers.
Neutrality proved difficult to maintain, though.
Alas, it proved difficult to find.
Genocide has proved difficult to prosecute.
The effect proved difficult to measure.
Yet reform proved difficult to implement.
The furlough plan proved difficult to enforce.
The advice proved difficult to follow.
The latter aim proved difficult to enforce.
Spectacular early results proved difficult to sustain.
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