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It has, however, proved difficult to elucidate the function of BMPs during ear development as mutations in these genes cause early embryonic lethality.
However, the enzyme activity of LARGE proved difficult to elucidate from sequence homologies alone.
Given the large evolutionary distance between yeasts and animals, it has proved difficult to elucidate the evolutionary history of cell cycle regulation and its relationship to the emergence of metazoans from their single-celled ancestors.
The evolutionary relationships between the members of this large superfamily are complicated and have proved difficult to elucidate [ 19], but understanding of the superfamily in angiosperms (specifically Arabidopsis, rice, and Populus) has improved through the use of genomic history to complement phylogenetic analysis [ 18, 20].
Although recent outbreaks of food-borne disease caused by E. coli and Salmonella have been well documented, and may, in part, be due to increased consumption of uncooked and organically grown vegetables, it has proved difficult to elucidate the full range of factors involved and therefore manage the risks to human health from pathogenic bacteria in the environment.
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As such, it may prove difficult to elucidate which components of the intervention (e.g. instructional methods vs. experiences) helped to demonstrate a specific outcome.
They have therefore proved difficult to compare using conventional sequence analysis techniques, and functions remain to be elucidated for most of them.
Yet reform proved difficult to implement.
The furlough plan proved difficult to enforce.
The advice proved difficult to follow.
Spectacular early results proved difficult to sustain.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com