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Despite their apparent universality, it proved difficult to derive biological conclusions from the patterns discovered in these initial global statistical analyses of molecular interaction networks.
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Consequently, alveolar epithelial cells have proven difficult to derive from both murine and human ESCs.
However, it has proved difficult to infer pathways from microarray data by deriving modules of multiple related genes, rather than individual genes.
The answers proved difficult to come by.
5, 6 Sarcopenia has proved difficult to define.
The role of health care proved difficult to define.
Such biological dosimeters were anticipated to provide direct measures of environmental pollutants and early detection of exposure effects, yet the quantification and precision needed for deriving exposure limits proved difficult to achieve; new biomarkers are hoped to fulfil this function.
Neutrality proved difficult to maintain, though.
Alas, it proved difficult to find.
Genocide has proved difficult to prosecute.
The effect proved difficult to measure.
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