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Although the toxicities were reversible, they were nevertheless of concern and it proved difficult to continue dosing for 7 days in some patients in the presence of a consistently rising creatinine.
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There are concerns that if bishops are excluded from the upper house, it will prove difficult to continue to allow the Church of England to remain the established church.
But it was proving difficult to keep track of such details as the lethal toll continued to rise.
This ideal proved difficult to realize, however, because of interference by politicians and the continuing presence of corruption within the system.
It soon became clear that it would be impractical to continue inventing new planetary symbols indefinitely, and some of the existing ones proved difficult to draw quickly.
Neutrality proved difficult to maintain, though.
Alas, it proved difficult to find.
Genocide has proved difficult to prosecute.
The effect proved difficult to measure.
Yet reform proved difficult to implement.
The furlough plan proved difficult to enforce.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com